MersV1, Main, Exploration, bibRecord, 004204

Cloning and genomic characterization of LST1 : a new gene in the human TNF region

Identifieur interne : 004204 ( Main/Exploration ); précédent : 004203; suivant : 004205

Cloning and genomic characterization of LST1 : a new gene in the human TNF region

Auteurs : Ingrid Holzinger [Autriche] ; Annegret De Baey [Allemagne] ; Gerald Messer [Allemagne] ; Gerold Kick [Allemagne] ; Heinz Zwierzina [Autriche] ; Elizabeth H. Weiss [Allemagne]

Source :

Immunogenetics [ 0093-7711 ] ; 1995-09-01.

RBID : ISTEX:7F3C2FBE5284EA537ABD6C1CAE9584C563C2B802

English descriptors

Teeft :
- Acad, Amino acids, Anal biochem, Autoimmune diseases, Base pairs, Bold type, Cdna, Cdna clone, Cdna sequence, Cdna synthesis, Cell biol, Cell line, Cerebral malaria, Clone, Codon, Cosmid cah5, Encodes, Eucaryotic ribosomes, Exon, Expression pattern, Gene, Genomic, Genomic characterization, Genomic localization, Genomic sequence, Haplotype, Histocompatibility, Holzinger, Human equivalent, Human genome, Human homolog, Human monocytic cell line monomac6, Hybridization, Hydrophobicity analysis, Immune response, Immunogenetics, Intercistronic length, Jurka, Kozak, Long orfs, Lst1, Lst1 cdna, Lst1 cdna clone, Lst1 codes, Lst1 gene, Lst1 genomic region, Lst1 mrna, Lst1 transcripts, Lsti, Major histocompatibility, Medium reiteration frequency, Messer, Microsatellites tnfd, Molecular basis, Mrna, Natl, Northern blot, Nucleic acids, Pfge mapping, Plstl, Polyadenylation signal, Polymorphic, Polymorphic markers, Possible role, Proc, Proc natl acad, Promoter region, Reading frames, Restriction fragments pst6, Restriction site, Restriction sites, Rflp analysis, Sequence analysis, Sequence conservation, Sequence similarity, Tnfa, Tnfd, Tnfe, Transcript, Transmembrane protein, Tumor necrosis factor, Weiss.

Abstract

Abstract: The leucocyte specific transcript — 1 (LST1) represents the human homolog of the mouse B144 transcript, encoded within the tumor necrosis factor (TNF) region of the human major histocompatibility complex class III interval. The gene is localized about 4 kilobases upstream of the lymphotoxin ß gene. It spans a polymorphic genomic region encompassing the microsatellites TNFd and TNFe in intron 3 and a polymorphic Pvu II restriction site 260 base pairs downstream of the polyadenylation signal. Isolation of a full-length cDNA clone revealed that LST1 codes for IFN-γ-inducible 800 nt transcripts, which are present in lymphoid tissues, T cells, macrophages, and histiocyte cell lines. The cDNA contains three long open reading frames (ORF) with the most likely ORF encoding a transmembrane protein. Its close linkage to the TNF genes and pattern of expression point toward a possible role for LST1 in the immune response.

Url:

https://api.istex.fr/ark:/67375/1BB-CBF5R8GW-F/fulltext.pdf

DOI: 10.1007/BF00179392

Affiliations:

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Le document en format XML

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<term>Bold type</term>
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<front><div type="abstract" xml:lang="en">Abstract: The leucocyte specific transcript — 1 (LST1) represents the human homolog of the mouse B144 transcript, encoded within the tumor necrosis factor (TNF) region of the human major histocompatibility complex class III interval. The gene is localized about 4 kilobases upstream of the lymphotoxin ß gene. It spans a polymorphic genomic region encompassing the microsatellites TNFd and TNFe in intron 3 and a polymorphic Pvu II restriction site 260 base pairs downstream of the polyadenylation signal. Isolation of a full-length cDNA clone revealed that LST1 codes for IFN-γ-inducible 800 nt transcripts, which are present in lymphoid tissues, T cells, macrophages, and histiocyte cell lines. The cDNA contains three long open reading frames (ORF) with the most likely ORF encoding a transmembrane protein. Its close linkage to the TNF genes and pattern of expression point toward a possible role for LST1 in the immune response.</div>
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Cloning and genomic characterization of LST1 : a new gene in the human TNF region

Cloning and genomic characterization of LST1 : a new gene in the human TNF region

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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